Cardiovascular Disease

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic.

CI-930 is a selective, orally active phosphodiesterase 3 (PDE3) inhibitor with an IC₅₀ value of 0.0.84 μM. CI-930 exerts positive inotropic and vasodilatory effects by inhibiting cAMP hydrolysis. CI-930 also regulates hemodynamics, inhibits the proliferation of coronary artery smooth muscle cells, and suppresses the proliferation of mouse splenocytes. CI-930 can be used in research related to heart failure, atherosclerosis, and asthma.

AR-9281 (Standard) is the analytical standard of AR-9281. This product is intended for research and analytical applications. AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes.

CGP-53353 (Standard) is the analytical standard of CGP-53353 (HY-108600). This product is intended for research and analytical applications. CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC₅₀s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients.

Nifekalant (hydrochloride) (Standard) is the analytical standard of Nifekalant (hydrochloride). This product is intended for research and analytical applications. Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC₅₀ of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research.

H142/08 is a β1-adrenergic receptor-selective agonist. H142/08 induces concentration-dependent relaxation of isolated rat uterus and acts as a chronotropic stimulant to increase atrial rate, and its effects are effectively antagonized by Pafenolol (HY-165495). H142/08 also antagonizes the chronotropic effect of isoproterenol on isolated rat right atrium, but requires a higher proportion of receptor occupancy to produce sufficient stimulatory effects.

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC₅₀ values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (K_ATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias.

L-770644 is an orally active, potent and selective agonist of the human β3 adrenergic receptor (EC₅₀ = 13 nM).

Octreotide-d₈ (SMS 201-995-d₈) TFA is the deuterium labeled Octreotide TFA. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.

Metformin-¹³C₂ (1,1-Dimethylbiguanide-¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H⁺/K⁺-ATPase with an IC₅₀ of 6.2 μM.

SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.

Isoxsuprine-monoester-1, a monoester of isoxsuprine, is a long acting peripheral vasodilator.

Calcium channel-modulator-1 is an orally active calcium channel modulator that blocks aortic contraction with an IC₅₀ of 0.8 μM. Calcium channel-modulator-1 can be used for the study of cardiovascular conditions.

VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC₅₀ of 7 nM.

TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.

CP-​060 is a potent Ca²⁺ antagonist, inhibits Ca²⁺ overload and possesses antioxidant and cardioprotective activities.

CS476 is a potent hypoglycaemic agent.

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with K_is of 25 and 26 nM for rat heart and canine aorta, respectively.